At the end of the second hour, it had already dropped to normal actually, on average it was slightly low. This gives the impression that even at brisk rates of infusion, the dextrose absorption mechanisms of a healthy person can keep up. Not only that, but the aforementioned healthy volunteers all ended up with glucose in their urine, which suggests that osmotic diuresis was taking place. It is difficult to quantify the amount of additional water lost in this way.
The metabolic and cardiovascular effects of intravenous infusion of glucose or intralipid in normal humans Clin Nutr. Also, see Dileep N. Lobo's excellent thesis on fluid physiology , which contains some interesting studies performed on healthy male volunteers. People dont do that sort of stuff any more, which is sad. Previous chapter: Physiology and pharmacology of colloid fluids Next chapter: Response to 1L of normal saline. All SAQs related to this topic.
Patients should address specific medical concerns with their physicians. Toggle navigation. Pharmacology Chapter. From Related Chapters. Obstetrics Endocrine Medications in Pregnancy. Page Contents You agree that we have no liability for any damages. What is 5 dextrose? What is Dextrose saline? This saline solution is a sterile solution which enters the body through intravenous administration Dextrose saline aids in electrolyte nourishment in the body.
Difference between 5 Dextrose and Dextrose saline Definition 5 dextrose It is an intravenous sugar solution which comprises of glucose and water.
It is composed of water and 50 gms of glucose Dextrose saline It is composed of dextrose, Sodium Chloride NaCl and water. Dextrose saline Dextrose saline is hypertonic A hypertonic solution is one in which the concentration of solutes is greater in the exterior of the cell than the interior of it.
Osmolarity 5 dextrose Osmolarity is about equal to serum, expands intravascular compartment. Dextrose saline Osmolarity is greater than the serum, draws fluid into the intravascular compartment through the cells and interstitial compartments.
Uses 5 dextrose It is used to treat low blood sugar hypoglycaemia , insulin shock, or fluid loss dehydration.
Dextrose saline Dextrose saline is an important source of electrolytes like Sodium Na and Chloride Cl ions. Summary of 5 Dextrose Vs. Dextrose saline: Comparison Chart The points of difference between 5 dextrose and Dextrose saline have been summarized below: Author Recent Posts. She has around 35 national and international publications to her credit. Latest posts by Dr.
Amita Fotedar -Dr see all. Help us improve. Data acquisition: YA and SU. Manuscript drafting: YA. All authors read and approved the final manuscript.
Correspondence to Yukari Aoyagi. The study protocol was approved by The Jikei University Institutional Review Board [] and the ethics committees of all other participating hospitals with an opt-out policy from the patient or their proxy. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Sensitivity analyses for multivariable logistic regression. Supplemental Table 2.
Sensitivity analyses for multivariable linear regression. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Reprints and Permissions. Aoyagi, Y. Download citation. Received : 09 July Accepted : 03 September Published : 11 September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background The choice of intravenous infusion products for critically ill patients has been studied extensively because it can affect prognosis.
Results We included patients: in the D5W period and in the saline period. Conclusions Changing the diluent default from D5W to saline had no effect on blood glucose control and increased the incidences of hypernatremia and hyperchloremia. Introduction Management of serum electrolyte and glucose levels among critically ill patients is essential because these abnormalities have been reported to be associated with acute kidney injury AKI and mortality [ 1 , 2 , 3 , 4 ]. Materials and methods We conducted a before-after, two-group comparative, observational study to retrospectively examine the effect of changing the drug diluent from D5W to saline.
Change of our policy Before the end of , D5W was automatically selected if the doctor did not specify the diluent when ordering intermittent drugs by the computer ordering system. Statistical methods Blood glucose standard deviation SD was calculated from all values measured during the observation period.
Results A total of adult patients were admitted to the ICU during the study period. Full size image. Table 1 Patient characteristics Full size table. Table 2 Infusion volume, electrolyte and glucose abnormalities, acute kidney injury, and other outcomes Full size table. Table 3 Multivariable regression analyses for primary outcomes Full size table. Table 4 Multivariable regression analyses for secondary outcomes Full size table. Discussion Key findings We conducted a before-after, two-group comparative study that examined the effect of changing the drug diluent from D5W to saline.
Comparison with previous studies There are few previous studies that evaluated the effect of diluent on patient outcomes [ 6 , 7 ]. Significance and implications We focused on the effect of the choice of drug diluent on outcomes in critically ill patients. Strengths and limitations We believe that the present study has the largest sample size among the studies assessing the choice of drug diluents for critically ill patients [ 6 , 7 ].
Conclusions Changing the drug diluent default from D5W to saline had no effect on blood glucose control but increased the incidence of hypernatremia and hyperchloremia, without affecting the incidence of AKI or mortality. For more information please email our Research Data Team. References 1. Article Google Scholar 6. Article Google Scholar 9. Article Google Scholar Article Google Scholar Download references.
Acknowledgements Not applicable. Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. View author publications. Ethics declarations Ethics approval and consent to participate The study protocol was approved by The Jikei University Institutional Review Board [] and the ethics committees of all other participating hospitals with an opt-out policy from the patient or their proxy.
Consent for publication Not applicable.
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